Endocrine Abstracts

Polycystic Ovary Syndrome (PCOS) is the most common endocrinological dysfunction among women of reproductive age, often featuring hyperandrogenemia and anovulation. Reciprocal effects exist between elevated LH, androgens, anovulation and other features, increasing the hormonal disbalance, while the origins of PCOS are still not fully clear. The neuropeptides Phoenixin-20 (PNX20) and Nesfatin1 (NES1) are being co-expressed and thought to play opposing roles in the hypothalamic&...

Purpose: To investigate the kinetics of adrenocorticotropin (ACTH) following oral metyrapone administration and describe differences between ACTH-deficient and non ACTH-deficient subjects.Methods: Patients from a tertiary endocrine center at a University Hospital in Munich, Germany, were tested. Metyrapone (Metopirone, HRA Pharma, France) was administered with a dosage of 40 mg/kg bodyweight at 0800 h. Consecutive levels of ACTH were determined at 0, 60,...

IntroductionWomen with PCOS frequently exhibit impaired insulin sensitivity. Low-grade chronic inflammation has been associated with insulin resistance and type 2 diabetes. DPP4, also known as CD26 (T-cell activation antigen CD26) is a prolin-specific serin-exopeptidase. With its binding partner ADA (Adenosine Deaminase complexing Protein) it cleaves numerous chemokines, mitogens, neuropeptides and peptide hormones and thereby influences metabolism, immu...

IntroductionThe polycystic ovary syndrome (PCOS) affects about 6–10% of women of reproductive age and is associated with oligomenorrhoea and anovulation. Recently, a possible impairment of bone accrual in women with PCOS due to the chronic inflammation disposition has been postulated [Kalyan, 2017]. The lack of progesterone due to anovulation may also have effects on bone metabolism [Seifert-Klauss, 2015]. A progestin test is a classic tool for asse...